{"id":2410,"date":"2024-05-20T13:50:08","date_gmt":"2024-05-20T13:50:08","guid":{"rendered":"https:\/\/lazarlabpenn.com\/?page_id=2410"},"modified":"2025-02-07T16:53:30","modified_gmt":"2025-02-07T16:53:30","slug":"lab-home","status":"publish","type":"page","link":"https:\/\/lazarlabpenn.com\/","title":{"rendered":"Lab Home"},"content":{"rendered":"<!--themify_builder_content-->\n<div id=\"themify_builder_content-2410\" data-postid=\"2410\" class=\"themify_builder_content themify_builder_content-2410 themify_builder tf_clear\">\n    \t\t\t\t<div  data-lazy=\"1\" class=\"module_row themify_builder_row tb_o42n478 tb_first tf_w\">\n\t\t\t\t\t\t<div class=\"row_inner col_align_top tb_col_count_1 tf_box tf_rel\">\n\t\t\t\t\t\t<div  data-lazy=\"1\" class=\"module_column tb-column col-full tb_7t69478 first\">\n\t\t\t\t\t<!-- module plain text -->\n<div  class=\"module module-plain-text tb_yb5l486 \" data-lazy=\"1\">\n        <div class=\"tb_text_wrap\">\n\t<h1 >Welcome to the Lazar Lab                                                    <\/h1>    <\/div>\n<\/div>\n<!-- \/module plain text -->\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<div  data-lazy=\"1\" class=\"module_row themify_builder_row tb_n1e2110 tf_w\">\n\t\t\t\t\t\t<div class=\"row_inner col_align_top tb_col_count_2 tf_box tf_rel\">\n\t\t\t\t\t\t<div  data-lazy=\"1\" class=\"module_column tb-column col4-2 tb_rczb210 first\">\n\t\t\t\t\t<!-- module plain text -->\n<div  class=\"module module-plain-text tb_wp7g810 \" data-lazy=\"1\">\n        <div class=\"tb_text_wrap\">\n\t<div class=\"ex1\">\n<br>\n\n                        \n                        \n                        \n                                                \n                        \n                                                                                                    \n                        \n                                                \n                        \n                        \n                        \n                        \n                        \n                       \n                            <p>The Lazar lab studies the transcriptional regulation of metabolism. Metabolic diseases, including diabetes and obesity, have a strong genetic basis, yet their increasing prevalence has been fueled by an environmental replete with fattening diets, insufficient physical activity, and exposure to light around the clock.&nbsp;<\/p>\n\n<h2>Our Goals<\/h2>\n\n<p>Understanding the molecular mechanisms underlying circadian and metabolic physiology, and how these contribute to homeostasis yet may be overcome by harmful environmental factors, leading to metabolic diseases.<\/p>\n<\/div>    <\/div>\n<\/div>\n<!-- \/module plain text -->\t\t<\/div>\n\t\t\t\t\t<div  data-lazy=\"1\" class=\"module_column tb-column col4-2 tb_e62m110 last\">\n\t\t\t\t\t<!-- module plain text -->\n<div  class=\"module module-plain-text tb_js2h958 \" data-lazy=\"1\">\n        <div class=\"tb_text_wrap\">\n\t\n<br>\n     <\/div>\n<\/div>\n<!-- \/module plain text -->\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<div  data-lazy=\"1\" class=\"module_row themify_builder_row tb_eo3t480 tf_w\">\n\t\t\t\t\t\t<div class=\"row_inner col_align_top tb_col_count_1 tf_box tf_rel\">\n\t\t\t\t\t\t<div  data-lazy=\"1\" class=\"module_column tb-column col-full tb_eugz480 first\">\n\t\t\t\t\t<!-- module plain text -->\n<div  class=\"module module-plain-text tb_95vt761 \" data-lazy=\"1\">\n        <div class=\"tb_text_wrap\">\n\t<div class=\"ex1\">\n<h2>Our Focus<\/h2>\n\n<ul>\n\t<li><strong>Nuclear receptor REV-ERB\u03b1<\/strong>, a key repressive component of the circadian clock that coordinates biological rhythms of metabolism in liver, adipose, and other tissues.<\/li>\n\t<li><strong>Nuclear receptor PPAR\u03b3,<\/strong> the master regulator of adipocyte biology, whose ligands have potent antidiabetic activity, a key transcriptional link between obesity and diabetes.<\/li>\n\t<li><strong>Thyroid hormone receptors,&nbsp;<\/strong>mediating the powerful metabolic effects of thyroid hormones, controlling energy metabolism&nbsp;<\/li>\n\t<li><strong>Nuclear receptor corepressors and histone deacetylase 3 (HDAC3),<\/strong>&nbsp;functioning as a multiprotein integrator of the function of nuclear receptors and other transcription factors, with tissue-specific functions that protect from challenges to the circadian, nutritional, and thermal environment.<\/li>\n\t<li><strong>Transcriptional regulation of circadian rhythms and metabolism,&nbsp;<\/strong>focused on the specific factors above as well as unbiased discovery of critical additional factors and pathways.<\/li>\n<\/ul>\n\n<h2>Our Approach<\/h2>\n\n<p>The Lazar lab has pioneered a systems approach to physiology that combines state-of-the-art in vivo &#8220;omics&#8221; with genetic and environmental manipulations and detailed metabolic phenotyping. This approach has had a major impact on our current understanding of the pathophysiology of obesity and diabetes, leading to new concepts linking the epigenome to metabolism and stimulating novel translational approaches for the treatment and prevention of metabolic diseases.&nbsp;<\/p>\n<\/div>    <\/div>\n<\/div>\n<!-- \/module plain text -->\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<div  data-lazy=\"1\" class=\"module_row themify_builder_row tb_ni350 tf_w\">\n\t\t\t\t\t\t<div class=\"row_inner col_align_top tb_col_count_1 tf_box tf_rel\">\n\t\t\t\t\t\t<div  data-lazy=\"1\" class=\"module_column tb-column col-full tb_1tw41 first\">\n\t\t\t\t\t<!-- module plain text -->\n<div  class=\"module module-plain-text tb_pupx62 \" data-lazy=\"1\">\n        <div class=\"tb_text_wrap\">\n\t<a href=\"https:\/\/lazarlabpenn.com\/index.php\/director\/\" >\n\tAbout Mitch Lazar <\/a>    <\/div>\n<\/div>\n<!-- \/module plain text -->\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n<!--\/themify_builder_content-->","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2410","page","type-page","status-publish","hentry","has-post-title","has-post-date","has-post-category","has-post-tag","has-post-comment","has-post-author",""],"builder_content":"<h1 >Welcome to the Lazar Lab <\/h1>\n<br>\n <p>The Lazar lab studies the transcriptional regulation of metabolism. Metabolic diseases, including diabetes and obesity, have a strong genetic basis, yet their increasing prevalence has been fueled by an environmental replete with fattening diets, insufficient physical activity, and exposure to light around the clock.&nbsp;<\/p>\n<h2>Our Goals<\/h2>\n<p>Understanding the molecular mechanisms underlying circadian and metabolic physiology, and how these contribute to homeostasis yet may be overcome by harmful environmental factors, leading to metabolic diseases.<\/p>\n<br> [smartslider3 slider=\"6\"]\n<h2>Our Focus<\/h2>\n<ul> <li><strong>Nuclear receptor REV-ERB\u03b1<\/strong>, a key repressive component of the circadian clock that coordinates biological rhythms of metabolism in liver, adipose, and other tissues.<\/li> <li><strong>Nuclear receptor PPAR\u03b3,<\/strong> the master regulator of adipocyte biology, whose ligands have potent antidiabetic activity, a key transcriptional link between obesity and diabetes.<\/li> <li><strong>Thyroid hormone receptors,&nbsp;<\/strong>mediating the powerful metabolic effects of thyroid hormones, controlling energy metabolism&nbsp;<\/li> <li><strong>Nuclear receptor corepressors and histone deacetylase 3 (HDAC3),<\/strong>&nbsp;functioning as a multiprotein integrator of the function of nuclear receptors and other transcription factors, with tissue-specific functions that protect from challenges to the circadian, nutritional, and thermal environment.<\/li> <li><strong>Transcriptional regulation of circadian rhythms and metabolism,&nbsp;<\/strong>focused on the specific factors above as well as unbiased discovery of critical additional factors and pathways.<\/li> <\/ul>\n<h2>Our Approach<\/h2>\n<p>The Lazar lab has pioneered a systems approach to physiology that combines state-of-the-art in vivo \"omics\" with genetic and environmental manipulations and detailed metabolic phenotyping. This approach has had a major impact on our current understanding of the pathophysiology of obesity and diabetes, leading to new concepts linking the epigenome to metabolism and stimulating novel translational approaches for the treatment and prevention of metabolic diseases.&nbsp;<\/p>\n<a href=\"https:\/\/lazarlabpenn.com\/index.php\/director\/\" > About Mitch Lazar <\/a>","_links":{"self":[{"href":"https:\/\/lazarlabpenn.com\/index.php\/wp-json\/wp\/v2\/pages\/2410","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lazarlabpenn.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lazarlabpenn.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lazarlabpenn.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lazarlabpenn.com\/index.php\/wp-json\/wp\/v2\/comments?post=2410"}],"version-history":[{"count":54,"href":"https:\/\/lazarlabpenn.com\/index.php\/wp-json\/wp\/v2\/pages\/2410\/revisions"}],"predecessor-version":[{"id":3325,"href":"https:\/\/lazarlabpenn.com\/index.php\/wp-json\/wp\/v2\/pages\/2410\/revisions\/3325"}],"wp:attachment":[{"href":"https:\/\/lazarlabpenn.com\/index.php\/wp-json\/wp\/v2\/media?parent=2410"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}