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2024

Inoue, Shin-Ichi; Emmett, Matthew J; Lim, Hee-Woong; Midha, Mohit; Richter, Hannah J; Celwyn, Isaac J; Mehmood, Rashid; Chondronikola, Maria; Klein, Samuel; Hauck, Amy K; Lazar, Mitchell A

Short-term cold exposure induces persistent epigenomic memory in brown fat Journal Article

In: Cell Metab, vol. 36, no. 8, pp. 1764–1778.e9, 2024, ISSN: 1932-7420.

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Paneru, Bam D; Chini, Julia; McCright, Sam J; DeMarco, Nicole; Miller, Jessica; Joannas, Leonel D; Henao-Mejia, Jorge; Titchenell, Paul M; Merrick, David M; Lim, Hee-Woong; Lazar, Mitchell A; Hill, David A

Myeloid-derived miR-6236 potentiates adipocyte insulin signaling and prevents hyperglycemia during obesity Journal Article

In: Nat Commun, vol. 15, no. 1, pp. 5394, 2024, ISSN: 2041-1723.

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Hauck, Amy K; Mehmood, Rashid; Carpenter, Bryce J; Frankfurter, Maxwell T; Tackenberg, Michael C; Inoue, Shin-Ichi; Krieg, Maria K; Bawa, Fathima N Cassim; Midha, Mohit K; Zundell, Delaine M; Batmanov, Kirill; Lazar, Mitchell A

Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis Journal Article

In: Nat Metab, 2024, ISSN: 2522-5812.

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Woodie, Lauren N; Melink, Lily C; Alberto, Ahren J; Burrows, Michelle; Fortin, Samantha M; Chan, Calvin C; Hayes, Matthew R; Lazar, Mitchell A

Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet-induced obesity and brown adipose tissue pathophysiology Journal Article

In: Mol Metab, vol. 79, pp. 101861, 2024, ISSN: 2212-8778.

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2023

Woodie, Lauren N; Melink, Lily C; Midha, Mohit; de Araújo, Alan M; Geisler, Caroline E; Alberto, Ahren J; Krusen, Brianna M; Zundell, Delaine M; de Lartigue, Guillaume; Hayes, Matthew R; Lazar, Mitchell A

Hepatic Vagal Afferents Convey Clock-Dependent Signals to Regulate Circadian Food Intake Journal Article

In: bioRxiv, 2023.

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Latimer, Mary N; Williams, Lamario J; Shanmugan, Gobinath; Carpenter, Bryce J; Lazar, Mitchell A; Dierickx, Pieterjan; Young, Martin E

Cardiomyocyte-specific disruption of the circadian BMAL1-REV-ERBα/β regulatory network impacts distinct miRNA species in the murine heart Journal Article

In: Commun Biol, vol. 6, no. 1, pp. 1149, 2023, ISSN: 2399-3642.

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Zhu, Kun; Celwyn, Isaac J; Guan, Dongyin; Xiao, Yang; Wang, Xiang; Hu, Wenxiang; Jiang, Chunjie; Cheng, Lan; Casellas, Rafael; Lazar, Mitchell A

An intrinsically disordered region controlling condensation of a circadian clock component and rhythmic transcription in the liver Journal Article

In: Mol Cell, vol. 83, no. 19, pp. 3457–3469.e7, 2023, ISSN: 1097-4164.

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Mia, Sobuj; Sonkar, Ravi; Williams, Lamario; Latimer, Mary N; Rawnsley, David R; Rana, Samir; He, Jin; Dierickx, Pieterjan; Kim, Teayoun; Xie, Min; Habegger, Kirk M; Kubo, Masato; Zhou, Lufang; Thomsen, Morten B; Prabhu, Sumanth D; Frank, Stuart J; Brookes, Paul S; Lazar, Mitchell A; Diwan, Abhinav; Young, Martin E

Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology Journal Article

In: JACC Basic Transl Sci, vol. 8, no. 9, pp. 1141–1156, 2023, ISSN: 2452-302X.

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Lee, Jiyeon; Dimitry, Julie M; Song, Jong Hee; Son, Minsoo; Sheehan, Patrick W; King, Melvin W; Tabor, G Travis; Goo, Young Ah; Lazar, Mitchell A; Petrucelli, Leonard; Musiek, Erik S

Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice Journal Article

In: Nat Commun, vol. 14, no. 1, pp. 5197, 2023, ISSN: 2041-1723.

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Yamamoto, Tsunehisa; Maurya, Santosh K; Pruzinsky, Elizabeth; Batmanov, Kirill; Xiao, Yang; Sulon, Sarah M; Sakamoto, Tomoya; Wang, Yang; Lai, Ling; McDaid, Kendra S; Shewale, Swapnil V; Leone, Teresa C; Koves, Timothy R; Muoio, Deborah M; Dierickx, Pieterjan; Lazar, Mitchell A; Lewandowski, E Douglas; Kelly, Daniel P

RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure Journal Article

In: J Clin Invest, vol. 133, no. 9, 2023, ISSN: 1558-8238.

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Adlanmerini, Marine; Lazar, Mitchell A

The REV-ERB Nuclear Receptors: Timekeepers for the Core Clock Period and Metabolism Journal Article

In: Endocrinology, vol. 164, no. 6, 2023, ISSN: 1945-7170.

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Guan, Dongyin; Bae, Hosung; Zhou, Dishu; Chen, Ying; Jiang, Chunjie; La, Cam Mong; Xiao, Yang; Zhu, Kun; Hu, Wenxiang; Trinh, Trang Minh; Liu, Panpan; Xiong, Ying; Cai, Bishuang; Jang, Cholsoon; Lazar, Mitchell A

Hepatocyte SREBP signaling mediates clock communication within the liver Journal Article

In: J Clin Invest, vol. 133, no. 8, 2023, ISSN: 1558-8238.

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Xiao, Yang; Batmanov, Kirill; Hu, Wenxiang; Zhu, Kun; Tom, Alexander Y; Guan, Dongyin; Jiang, Chunjie; Cheng, Lan; McCright, Sam J; Yang, Eric C; Lanza, Matthew R; Liu, Yifan; Hill, David A; Lazar, Mitchell A

Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis Journal Article

In: Sci Transl Med, vol. 15, no. 682, pp. eadc9653, 2023, ISSN: 1946-6242.

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Lazar, Mitchell A

Genes and my development Journal Article

In: Genes Dev, vol. 37, no. 1-2, pp. 35–36, 2023, ISSN: 1549-5477.

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2022

Hu, Wenxiang; Lazar, Mitchell A

Modelling metabolic diseases and drug response using stem cells and organoids Journal Article

In: Nat Rev Endocrinol, vol. 18, no. 12, pp. 744–759, 2022, ISSN: 1759-5037.

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Lazar, Mitchell A

Tugs-of-war in science Journal Article

In: J Clin Invest, vol. 132, no. 20, 2022, ISSN: 1558-8238.

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Xiao, Tianli; Langston, P Kent; Muñoz-Rojas, Andrés R; Jayewickreme, Teshika; Lazar, Mitchell A; Benoist, Christophe; Mathis, Diane

T in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis Journal Article

In: Sci Immunol, vol. 7, no. 75, pp. eabl7641, 2022, ISSN: 2470-9468.

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Richter, Hannah J; Hauck, Amy K; Batmanov, Kirill; Inoue, Shin-Ichi; So, Bethany N; Kim, Mindy; Emmett, Matthew J; Cohen, Ronald N; Lazar, Mitchell A

Balanced control of thermogenesis by nuclear receptor corepressors in brown adipose tissue Journal Article

In: Proc Natl Acad Sci U S A, vol. 119, no. 33, pp. e2205276119, 2022, ISSN: 1091-6490.

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Woodie, Lauren N; Oral, Kaan T; Krusen, Brianna M; Lazar, Mitchell A

The Circadian Regulation of Nutrient Metabolism in Diet-Induced Obesity and Metabolic Disease Journal Article

In: Nutrients, vol. 14, no. 15, 2022, ISSN: 2072-6643.

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Santoleri, Dominic; Lim, Hee-Woong; Emmett, Matthew J; Stoute, Julian; Gavin, Matthew J; Sostre-Colón, Jaimarie; Uehara, Kahealani; Welles, Jaclyn E; Liu, Kathy Fange; Lazar, Mitchell A; Titchenell, Paul M

Global-run on sequencing identifies as an Akt-dependent long noncoding RNA involved in insulin sensitivity Journal Article

In: iScience, vol. 25, no. 6, pp. 104410, 2022, ISSN: 2589-0042.

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Chen, Zhong; Ye, Zhenqing; Soccio, Raymond E; Nakadai, Tomoyoshi; Hankey, William; Zhao, Yue; Huang, Furong; Yuan, Fuwen; Wang, Hongyan; Cui, Zhifen; Sunkel, Benjamin; Wu, Dayong; Dzeng, Richard K; Thomas-Ahner, Jennifer M; Huang, Tim H M; Clinton, Steven K; Huang, Jiaoti; Lazar, Mitchell A; Jin, Victor X; Roeder, Robert G; Wang, Qianben

Phosphorylated MED1 links transcription recycling and cancer growth Journal Article

In: Nucleic Acids Res, vol. 50, no. 8, pp. 4450–4463, 2022, ISSN: 1362-4962.

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Guan, Dongyin; Lazar, Mitchell A

Circadian Regulation of Gene Expression and Metabolism in the Liver Journal Article

In: Semin Liver Dis, vol. 42, no. 2, pp. 113–121, 2022, ISSN: 1098-8971.

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Hu, Wenxiang; Jiang, Chunjie; Kim, Mindy; Xiao, Yang; Richter, Hannah J; Guan, Dongyin; Zhu, Kun; Krusen, Brianna M; Roberts, Arielle N; Miller, Jessica; Steger, David J; Lazar, Mitchell A

Isoform-specific functions of PPARγ in gene regulation and metabolism Journal Article

In: Genes Dev, vol. 36, no. 5-6, pp. 300–312, 2022, ISSN: 1549-5477.

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Dierickx, Pieterjan; Zhu, Kun; Carpenter, Bryce J; Jiang, Chunjie; Vermunt, Marit W; Xiao, Yang; Luongo, Timothy S; Yamamoto, Tsunehisa; Martí-Pàmies, Íngrid; Mia, Sobuj; Latimer, Mary; Diwan, Abhinav; Zhao, Juanjuan; Hauck, Amy K; Krusen, Brianna; Nguyen, Hoang C B; Blobel, Gerd A; Kelly, Daniel P; Pei, Liming; Baur, Joseph A; Young, Martin E; Lazar, Mitchell A

Circadian REV-ERBs repress to activate NAMPT-dependent NAD biosynthesis and sustain cardiac function Journal Article

In: Nat Cardiovasc Res, vol. 1, no. 1, pp. 45–58, 2022, ISSN: 2731-0590.

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Dierickx, Pieterjan; Carpenter, Bryce J; Celwyn, Isaac; Kelly, Daniel P; Baur, Joseph A; Lazar, Mitchell A

Nicotinamide Riboside Improves Cardiac Function and Prolongs Survival After Disruption of the Cardiomyocyte Clock Journal Article

In: Front Mol Med, vol. 2, 2022, ISSN: 2674-0095.

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2021

Adlanmerini, Marine; Krusen, Brianna M; Nguyen, Hoang C B; Teng, Clare W; Woodie, Lauren N; Tackenberg, Michael C; Geisler, Caroline E; Gaisinsky, Jane; Peed, Lindsey C; Carpenter, Bryce J; Hayes, Matthew R; Lazar, Mitchell A

REV-ERB nuclear receptors in the suprachiasmatic nucleus control circadian period and restrict diet-induced obesity Journal Article

In: Sci Adv, vol. 7, no. 44, pp. eabh2007, 2021, ISSN: 2375-2548.

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Lazar, Mitchell A

Novel biomedical research must not be a work of fiction Miscellaneous

2021, ISSN: 1558-8238.

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Guan, Dongyin; Lazar, Mitchell A

Interconnections between circadian clocks and metabolism Journal Article

In: J Clin Invest, vol. 131, no. 15, 2021, ISSN: 1558-8238.

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Hu, Wenxiang; Jiang, Chunjie; Kim, Mindy; Yang, Wenjian; Zhu, Kun; Guan, Dongyin; Lv, Wenjian; Xiao, Yang; Wilson, Jessica R; Rader, Daniel J; Pui, Ching-Hon; Relling, Mary V; Lazar, Mitchell A

Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids Journal Article

In: Cell Metab, vol. 33, no. 8, pp. 1592–1609.e7, 2021, ISSN: 1932-7420.

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Xiao, Yang; Kim, Mindy; Lazar, Mitchell A

Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease Journal Article

In: Mol Metab, vol. 50, pp. 101119, 2021, ISSN: 2212-8778.

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Shabtai, Yehuda; Nagaraj, Nagaswaroop K; Batmanov, Kirill; Cho, Young-Wook; Guan, Yuxia; Jiang, Chunjie; Remsberg, Jarrett; Forrest, Douglas; Lazar, Mitchell A

A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver Journal Article

In: Genes Dev, vol. 35, no. 5-6, pp. 367–378, 2021, ISSN: 1549-5477.

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Gillen, Austin E; Fu, Rui; Riemondy, Kent A; Jager, Jennifer; Fang, Bin; Lazar, Mitchell A; Martin, Sandra L

Liver Transcriptome Dynamics During Hibernation Are Shaped by a Shifting Balance Between Transcription and RNA Stability Journal Article

In: Front Physiol, vol. 12, pp. 662132, 2021, ISSN: 1664-042X.

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Fang, Bin; Guan, Dongyin; Lazar, Mitchell A

Using GRO-Seq to Measure Circadian Transcription and Discover Circadian Enhancers Journal Article

In: Methods Mol Biol, vol. 2130, pp. 127–148, 2021, ISSN: 1940-6029.

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Adlanmerini, Marine; Nguyen, Hoang Cb; Krusen, Brianna M; Teng, Clare W; Geisler, Caroline E; Peed, Lindsey C; Carpenter, Bryce J; Hayes, Matthew R; Lazar, Mitchell A

Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice Journal Article

In: J Clin Invest, vol. 131, no. 1, 2021, ISSN: 1558-8238.

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2020

Kim, Yong Hoon; Lazar, Mitchell A

Transcriptional Control of Circadian Rhythms and Metabolism: A Matter of Time and Space Journal Article

In: Endocr Rev, vol. 41, no. 5, pp. 707–732, 2020, ISSN: 1945-7189.

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Guan, Dongyin; Xiong, Ying; Trinh, Trang Minh; Xiao, Yang; Hu, Wenxiang; Jiang, Chunjie; Dierickx, Pieterjan; Jang, Cholsoon; Rabinowitz, Joshua D; Lazar, Mitchell A

The hepatocyte clock and feeding control chronophysiology of multiple liver cell types Journal Article

In: Science, vol. 369, no. 6509, pp. 1388–1394, 2020, ISSN: 1095-9203.

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Nguyen, Hoang C B; Adlanmerini, Marine; Hauck, Amy K; Lazar, Mitchell A

Dichotomous engagement of HDAC3 activity governs inflammatory responses Journal Article

In: Nature, vol. 584, no. 7820, pp. 286–290, 2020, ISSN: 1476-4687.

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Szigety, Katherine M; Liu, Fang; Yuan, Chase Y; Moran, Deborah J; Horrell, Jeremy; Gochnauer, Heather R; Cohen, Ronald N; Katz, Jonathan P; Kaestner, Klaus H; Seykora, John T; Tobias, John W; Lazar, Mitchell A; Xu, Mingang; Millar, Sarah E

HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity Journal Article

In: Genes Dev, vol. 34, no. 13-14, pp. 973–988, 2020, ISSN: 1549-5477.

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Angueira, Anthony R; Shapira, Suzanne N; Ishibashi, Jeff; Sampat, Samay; Sostre-Colón, Jaimarie; Emmett, Matthew J; Titchenell, Paul M; Lazar, Mitchell A; Lim, Hee-Woong; Seale, Patrick

Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes Journal Article

In: Cell Rep, vol. 30, no. 9, pp. 2869–2878.e4, 2020, ISSN: 2211-1247.

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2019

Guan, Dongyin; Lazar, Mitchell A

Shining light on dark matter in the genome Journal Article

In: Proc Natl Acad Sci U S A, vol. 116, no. 50, pp. 24919–24921, 2019, ISSN: 1091-6490.

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Kuo, Taiyi; Kraakman, Michael J; Damle, Manashree; Gill, Richard; Lazar, Mitchell A; Accili, Domenico

Identification of as a human diabetes susceptibility gene with a role in β cell insulin secretion Journal Article

In: Proc Natl Acad Sci U S A, vol. 116, no. 40, pp. 20033–20042, 2019, ISSN: 1091-6490.

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Adlanmerini, Marine; Carpenter, Bryce J; Remsberg, Jarrett R; Aubert, Yann; Peed, Lindsey C; Richter, Hannah J; Lazar, Mitchell A

Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold Journal Article

In: Proc Natl Acad Sci U S A, vol. 116, no. 37, pp. 18691–18699, 2019, ISSN: 1091-6490.

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Jaitin, Diego Adhemar; Adlung, Lorenz; Thaiss, Christoph A; Weiner, Assaf; Li, Baoguo; Descamps, Hélène; Lundgren, Patrick; Bleriot, Camille; Liu, Zhaoyuan; Deczkowska, Aleksandra; Keren-Shaul, Hadas; David, Eyal; Zmora, Niv; Eldar, Shai Meron; Lubezky, Nir; Shibolet, Oren; Hill, David A; Lazar, Mitchell A; Colonna, Marco; Ginhoux, Florent; Shapiro, Hagit; Elinav, Eran; Amit, Ido

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner Journal Article

In: Cell, vol. 178, no. 3, pp. 686–698.e14, 2019, ISSN: 1097-4172.

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Dierickx, Pieterjan; Emmett, Matthew J; Jiang, Chunjie; Uehara, Kahealani; Liu, Manlu; Adlanmerini, Marine; Lazar, Mitchell A

SR9009 has REV-ERB-independent effects on cell proliferation and metabolism Journal Article

In: Proc Natl Acad Sci U S A, vol. 116, no. 25, pp. 12147–12152, 2019, ISSN: 1091-6490.

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Kuo, Taiyi; Damle, Manashree; González, Bryan J; Egli, Dieter; Lazar, Mitchell A; Accili, Domenico

Induction of α cell-restricted Gc in dedifferentiating β cells contributes to stress-induced β-cell dysfunction Journal Article

In: JCI Insight, vol. 5, no. 13, 2019, ISSN: 2379-3708.

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Dallner, Olof S; Marinis, Jill M; Lu, Yi-Hsueh; Birsoy, Kivanc; Werner, Emory; Fayzikhodjaeva, Gulya; Dill, Brian D; Molina, Henrik; Moscati, Arden; Kutalik, Zoltán; Marques-Vidal, Pedro; Kilpeläinen, Tuomas O; Grarup, Niels; Linneberg, Allan; Zhang, Yinxin; Vaughan, Roger; Loos, Ruth J F; Lazar, Mitchell A; Friedman, Jeffrey M

Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity Journal Article

In: Nat Med, vol. 25, no. 3, pp. 507–516, 2019, ISSN: 1546-170X.

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Hu, Wenxiang; Jiang, Chunjie; Guan, Dongyin; Dierickx, Pieterjan; Zhang, Rong; Moscati, Arden; Nadkarni, Girish N; Steger, David J; Loos, Ruth J F; Hu, Cheng; Jia, Weiping; Soccio, Raymond E; Lazar, Mitchell A

Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response Journal Article

In: Cell Stem Cell, vol. 24, no. 2, pp. 299–308.e6, 2019, ISSN: 1875-9777.

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Emmett, Matthew J; Lazar, Mitchell A

Integrative regulation of physiology by histone deacetylase 3 Journal Article

In: Nat Rev Mol Cell Biol, vol. 20, no. 2, pp. 102–115, 2019, ISSN: 1471-0080.

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2018

Koerner, Martha V; FitzPatrick, Laura; Selfridge, Jim; Guy, Jacky; Sousa, Dina De; Tillotson, Rebekah; Kerr, Alastair; Sun, Zheng; Lazar, Mitchell A; Lyst, Matthew J; Bird, Adrian

Toxicity of overexpressed MeCP2 is independent of HDAC3 activity Journal Article

In: Genes Dev, vol. 32, no. 23-24, pp. 1514–1524, 2018, ISSN: 1549-5477.

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Razzoli, Maria; Emmett, Matthew J; Lazar, Mitchell A; Bartolomucci, Alessandro

β-Adrenergic receptors control brown adipose UCP-1 tone and cold response without affecting its circadian rhythmicity Journal Article

In: FASEB J, vol. 32, no. 10, pp. 5640–5646, 2018, ISSN: 1530-6860.

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268 entries « 1 of 6 »