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2018

Borck, Patricia C; Batista, Thiago M; Vettorazzi, Jean F; Soares, Gabriela M; Lubaczeuski, Camila; Guan, Dongyin; Boschero, Antonio C; Vieira, Elaine; Lazar, Mitchell A; Carneiro, Everardo M

Nighttime light exposure enhances Rev-erbα-targeting microRNAs and contributes to hepatic steatosis Journal Article

In: Metabolism, vol. 85, pp. 250–258, 2018, ISSN: 1532-8600.

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Zhang, Yinxin; Dallner, Olof Stefan; Nakadai, Tomoyoshi; Fayzikhodjaeva, Gulya; Lu, Yi-Hsueh; Lazar, Mitchell A; Roeder, Robert G; Friedman, Jeffrey M

A noncanonical PPARγ/RXRα-binding sequence regulates leptin expression in response to changes in adipose tissue mass Journal Article

In: Proc Natl Acad Sci U S A, vol. 115, no. 26, pp. E6039–E6047, 2018, ISSN: 1091-6490.

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Lazar, Mitchell A

Reversing the curse on PPARγ Journal Article

In: J Clin Invest, vol. 128, no. 6, pp. 2202–2204, 2018, ISSN: 1558-8238.

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Hill, David A; Lim, Hee-Woong; Kim, Yong Hoon; Ho, Wesley Y; Foong, Yee Hoon; Nelson, Victoria L; Nguyen, Hoang C B; Chegireddy, Kavya; Kim, Jihoon; Habertheuer, Andreas; Vallabhajosyula, Prashanth; Kambayashi, Taku; Won, Kyoung-Jae; Lazar, Mitchell A

Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue Journal Article

In: Proc Natl Acad Sci U S A, vol. 115, no. 22, pp. E5096–E5105, 2018, ISSN: 1091-6490.

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Kim, Yong Hoon; Marhon, Sajid A; Zhang, Yuxiang; Steger, David J; Won, Kyoung-Jae; Lazar, Mitchell A

Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription Journal Article

In: Science, vol. 359, no. 6381, pp. 1274–1277, 2018, ISSN: 1095-9203.

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2017

Jang, Jessica C; Li, Jiang; Gambini, Luca; Batugedara, Hashini M; Sati, Sandeep; Lazar, Mitchell A; Fan, Li; Pellecchia, Maurizio; Nair, Meera G

Human resistin protects against endotoxic shock by blocking LPS-TLR4 interaction Journal Article

In: Proc Natl Acad Sci U S A, vol. 114, no. 48, pp. E10399–E10408, 2017, ISSN: 1091-6490.

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Poleshko, Andrey; Shah, Parisha P; Gupta, Mudit; Babu, Apoorva; Morley, Michael P; Manderfield, Lauren J; Ifkovits, Jamie L; Calderon, Damelys; Aghajanian, Haig; Sierra-Pagán, Javier E; Sun, Zheng; Wang, Qiaohong; Li, Li; Dubois, Nicole C; Morrisey, Edward E; Lazar, Mitchell A; Smith, Cheryl L; Epstein, Jonathan A; Jain, Rajan

Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction Journal Article

In: Cell, vol. 171, no. 3, pp. 573–587.e14, 2017, ISSN: 1097-4172.

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Armour, Sean M; Remsberg, Jarrett R; Damle, Manashree; Sidoli, Simone; Ho, Wesley Y; Li, Zhenghui; Garcia, Benjamin A; Lazar, Mitchell A

An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides Journal Article

In: Nat Commun, vol. 8, no. 1, pp. 549, 2017, ISSN: 2041-1723.

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Titchenell, Paul M; Lazar, Mitchell A; Birnbaum, Morris J

Unraveling the Regulation of Hepatic Metabolism by Insulin Journal Article

In: Trends Endocrinol Metab, vol. 28, no. 7, pp. 497–505, 2017, ISSN: 1879-3061.

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Zhang, Yuxiang; Papazyan, Romeo; Damle, Manashree; Fang, Bin; Jager, Jennifer; Feng, Dan; Peed, Lindsey C; Guan, Dongyin; Sun, Zheng; Lazar, Mitchell A

The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ Journal Article

In: Genes Dev, vol. 31, no. 12, pp. 1202–1211, 2017, ISSN: 1549-5477.

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Emmett, Matthew J; Lim, Hee-Woong; Jager, Jennifer; Richter, Hannah J; Adlanmerini, Marine; Peed, Lindsey C; Briggs, Erika R; Steger, David J; Ma, Tao; Sims, Carrie A; Baur, Joseph A; Pei, Liming; Won, Kyoung-Jae; Seale, Patrick; Gerhart-Hines, Zachary; Lazar, Mitchell A

Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge Journal Article

In: Nature, vol. 546, no. 7659, pp. 544–548, 2017, ISSN: 1476-4687.

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Lazar, Mitchell A

Maturing of the nuclear receptor family Journal Article

In: J Clin Invest, vol. 127, no. 4, pp. 1123–1125, 2017, ISSN: 1558-8238.

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Soccio, Raymond E; Li, Zhenghui; Chen, Eric R; Foong, Yee Hoon; Benson, Kiara K; Dispirito, Joanna R; Mullican, Shannon E; Emmett, Matthew J; Briggs, Erika R; Peed, Lindsey C; Dzeng, Richard K; Medina, Carlos J; Jolivert, Jennifer F; Kissig, Megan; Rajapurkar, Satyajit R; Damle, Manashree; Lim, Hee-Woong; Won, Kyoung-Jae; Seale, Patrick; Steger, David J; Lazar, Mitchell A

Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice Journal Article

In: J Clin Invest, vol. 127, no. 4, pp. 1451–1462, 2017, ISSN: 1558-8238.

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Plikus, Maksim V; Guerrero-Juarez, Christian F; Ito, Mayumi; Li, Yun Rose; Dedhia, Priya H; Zheng, Ying; Shao, Mengle; Gay, Denise L; Ramos, Raul; Hsi, Tsai-Ching; Oh, Ji Won; Wang, Xiaojie; Ramirez, Amanda; Konopelski, Sara E; Elzein, Arijh; Wang, Anne; Supapannachart, Rarinthip June; Lee, Hye-Lim; Lim, Chae Ho; Nace, Arben; Guo, Amy; Treffeisen, Elsa; Andl, Thomas; Ramirez, Ricardo N; Murad, Rabi; Offermanns, Stefan; Metzger, Daniel; Chambon, Pierre; Widgerow, Alan D; Tuan, Tai-Lan; Mortazavi, Ali; Gupta, Rana K; Hamilton, Bruce A; Millar, Sarah E; Seale, Patrick; Pear, Warren S; Lazar, Mitchell A; Cotsarelis, George

Regeneration of fat cells from myofibroblasts during wound healing Journal Article

In: Science, vol. 355, no. 6326, pp. 748–752, 2017, ISSN: 1095-9203.

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Hong, Sungguan; Zhou, Wenjun; Fang, Bin; Lu, Wenyun; Loro, Emanuele; Damle, Manashree; Ding, Guolian; Jager, Jennifer; Zhang, Sisi; Zhang, Yuxiang; Feng, Dan; Chu, Qingwei; Dill, Brian D; Molina, Henrik; Khurana, Tejvir S; Rabinowitz, Joshua D; Lazar, Mitchell A; Sun, Zheng

Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion Journal Article

In: Nat Med, vol. 23, no. 2, pp. 223–234, 2017, ISSN: 1546-170X.

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Remsberg, Jarrett R; Ediger, Benjamin N; Ho, Wesley Y; Damle, Manashree; Li, Zhenghui; Teng, Christopher; Lanzillotta, Cristina; Stoffers, Doris A; Lazar, Mitchell A

Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion Journal Article

In: Mol Metab, vol. 6, no. 1, pp. 30–37, 2017, ISSN: 2212-8778.

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2016

Papazyan, Romeo; Zhang, Yuxiang; Lazar, Mitchell A

Genetic and epigenomic mechanisms of mammalian circadian transcription Journal Article

In: Nat Struct Mol Biol, vol. 23, no. 12, pp. 1045–1052, 2016, ISSN: 1545-9985.

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Papazyan, Romeo; Sun, Zheng; Kim, Yong Hoon; Titchenell, Paul M; Hill, David A; Lu, Wenyun; Damle, Manashree; Wan, Min; Zhang, Yuxiang; Briggs, Erika R; Rabinowitz, Joshua D; Lazar, Mitchell A

Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP Journal Article

In: Cell Metab, vol. 24, no. 6, pp. 863–874, 2016, ISSN: 1932-7420.

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Bass, Joseph; Lazar, Mitchell A

Circadian time signatures of fitness and disease Journal Article

In: Science, vol. 354, no. 6315, pp. 994–999, 2016, ISSN: 1095-9203.

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Ferrannini, Giulia; Namwanje, Maria; Fang, Bin; Damle, Manashree; Li, Dylan; Liu, Qiongming; Lazar, Mitchell A; Qiang, Li

Genetic backgrounds determine brown remodeling of white fat in rodents Journal Article

In: Mol Metab, vol. 5, no. 10, pp. 948–958, 2016, ISSN: 2212-8778.

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Teng, Xin; Emmett, Matthew J; Lazar, Mitchell A; Goldberg, Erwin; Rabinowitz, Joshua D

Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis Journal Article

In: ACS Chem Biol, vol. 11, no. 9, pp. 2420–2427, 2016, ISSN: 1554-8937.

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Zhang, Yuxiang; Fang, Bin; Damle, Manashree; Guan, Dongyin; Li, Zhenghui; Kim, Yong Hoon; Gannon, Maureen; Lazar, Mitchell A

HNF6 and Rev-erbα integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms Journal Article

In: Genes Dev, vol. 30, no. 14, pp. 1636–1644, 2016, ISSN: 1549-5477.

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Zhang, Liguo; He, Xuelian; Liu, Lei; Jiang, Minqing; Zhao, Chuntao; Wang, Haibo; He, Danyang; Zheng, Tao; Zhou, Xianyao; Hassan, Aishlin; Ma, Zhixing; Xin, Mei; Sun, Zheng; Lazar, Mitchell A; Goldman, Steven A; Olson, Eric N; Lu, Q Richard

Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch Journal Article

In: Dev Cell, vol. 37, no. 6, pp. 582, 2016, ISSN: 1878-1551.

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Jager, Jennifer; Wang, Fenfen; Fang, Bin; Lim, Hee-Woong; Peed, Lindsey C; Steger, David J; Won, Kyoung-Jae; Kharitonenkov, Alexei; Adams, Andrew C; Lazar, Mitchell A

The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling Journal Article

In: J Biol Chem, vol. 291, no. 20, pp. 10867–10875, 2016, ISSN: 1083-351X.

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Zhang, Liguo; He, Xuelian; Liu, Lei; Jiang, Minqing; Zhao, Chuntao; Wang, Haibo; He, Danyang; Zheng, Tao; Zhou, Xianyao; Hassan, Aishlin; Ma, Zhixing; Xin, Mei; Sun, Zheng; Lazar, Mitchell A; Goldman, Steven A; Olson, Eric N; Lu, Q Richard

Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch Journal Article

In: Dev Cell, vol. 36, no. 3, pp. 316–330, 2016, ISSN: 1878-1551.

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Wang, Yi; Frank, David B; Morley, Michael P; Zhou, Su; Wang, Xiaoru; Lu, Min Min; Lazar, Mitchell A; Morrisey, Edward E

HDAC3-Dependent Epigenetic Pathway Controls Lung Alveolar Epithelial Cell Remodeling and Spreading via miR-17-92 and TGF-β Signaling Regulation Journal Article

In: Dev Cell, vol. 36, no. 3, pp. 303–315, 2016, ISSN: 1878-1551.

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2015

Altman, Brian J; Hsieh, Annie L; Sengupta, Arjun; Krishnanaiah, Saikumari Y; Stine, Zachary E; Walton, Zandra E; Gouw, Arvin M; Venkataraman, Anand; Li, Bo; Goraksha-Hicks, Pankuri; Diskin, Sharon J; Bellovin, David I; Simon, M Celeste; Rathmell, Jeffrey C; Lazar, Mitchell A; Maris, John M; Felsher, Dean W; Hogenesch, John B; Weljie, Aalim M; Dang, Chi V

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells Journal Article

In: Cell Metab, vol. 22, no. 6, pp. 1009–1019, 2015, ISSN: 1932-7420.

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Gerhart-Hines, Z; Lazar, M A

Rev-erbα and the circadian transcriptional regulation of metabolism Journal Article

In: Diabetes Obes Metab, vol. 17 Suppl 1, no. 0 1, pp. 12–16, 2015, ISSN: 1463-1326.

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Soccio, Raymond E; Chen, Eric R; Rajapurkar, Satyajit R; Safabakhsh, Pegah; Marinis, Jill M; Dispirito, Joanna R; Emmett, Matthew J; Briggs, Erika R; Fang, Bin; Everett, Logan J; Lim, Hee-Woong; Won, Kyoung-Jae; Steger, David J; Wu, Ying; Civelek, Mete; Voight, Benjamin F; Lazar, Mitchell A

Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo Journal Article

In: Cell, vol. 162, no. 1, pp. 33–44, 2015, ISSN: 1097-4172.

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Cohen, Daniel M; Won, Kyoung-Jae; Nguyen, Nha; Lazar, Mitchell A; Chen, Christopher S; Steger, David J

ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis Journal Article

In: Elife, vol. 4, pp. e06821, 2015, ISSN: 2050-084X.

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Zhang, Yuxiang; Fang, Bin; Emmett, Matthew J; Damle, Manashree; Sun, Zheng; Feng, Dan; Armour, Sean M; Remsberg, Jarrett R; Jager, Jennifer; Soccio, Raymond E; Steger, David J; Lazar, Mitchell A

GENE REGULATION. Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock Journal Article

In: Science, vol. 348, no. 6242, pp. 1488–1492, 2015, ISSN: 1095-9203.

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Lim, Hee-Woong; Uhlenhaut, N Henriette; Rauch, Alexander; Weiner, Juliane; Hübner, Sabine; Hübner, Norbert; Won, Kyoung-Jae; Lazar, Mitchell A; Tuckermann, Jan; Steger, David J

Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo Journal Article

In: Genome Res, vol. 25, no. 6, pp. 836–844, 2015, ISSN: 1549-5469.

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Gerhart-Hines, Zachary; Lazar, Mitchell A

Circadian metabolism in the light of evolution Journal Article

In: Endocr Rev, vol. 36, no. 3, pp. 289–304, 2015, ISSN: 1945-7189.

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Harms, Matthew J; Lim, Hee-Woong; Ho, Yugong; Shapira, Suzanne N; Ishibashi, Jeff; Rajakumari, Sona; Steger, David J; Lazar, Mitchell A; Won, Kyoung-Jae; Seale, Patrick

PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program Journal Article

In: Genes Dev, vol. 29, no. 3, pp. 298–307, 2015, ISSN: 1549-5477.

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Fang, Bin; Lazar, Mitchell A

Dissecting the Rev-erbα Cistrome and the Mechanisms Controlling Circadian Transcription in Liver Journal Article

In: Cold Spring Harb Symp Quant Biol, vol. 80, pp. 233–238, 2015, ISSN: 1943-4456.

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Jang, Jessica C; Chen, Gang; Wang, Spencer H; Barnes, Mark A; Chung, Josiah I; Camberis, Mali; Gros, Graham Le; Cooper, Philip J; Steel, Cathy; Nutman, Thomas B; Lazar, Mitchell A; Nair, Meera G

Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden Journal Article

In: PLoS Pathog, vol. 11, no. 1, pp. e1004579, 2015, ISSN: 1553-7374.

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2014

Lee, Jae Man; Wagner, Martin; Xiao, Rui; Kim, Kang Ho; Feng, Dan; Lazar, Mitchell A; Moore, David D

Nutrient-sensing nuclear receptors coordinate autophagy Journal Article

In: Nature, vol. 516, no. 7529, pp. 112–115, 2014, ISSN: 1476-4687.

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Fang, Bin; Everett, Logan J; Jager, Jennifer; Briggs, Erika; Armour, Sean M; Feng, Dan; Roy, Ankur; Gerhart-Hines, Zachary; Sun, Zheng; Lazar, Mitchell A

Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo Journal Article

In: Cell, vol. 159, no. 5, pp. 1140–1152, 2014, ISSN: 1097-4172.

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Everett, Logan J; Lazar, Mitchell A

Nuclear receptor Rev-erbα: up, down, and all around Journal Article

In: Trends Endocrinol Metab, vol. 25, no. 11, pp. 586–592, 2014, ISSN: 1879-3061.

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Soccio, Raymond E; Chen, Eric R; Lazar, Mitchell A

Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes Journal Article

In: Cell Metab, vol. 20, no. 4, pp. 573–591, 2014, ISSN: 1932-7420.

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Gardini, Alessandro; Baillat, David; Cesaroni, Matteo; Hu, Deqing; Marinis, Jill M; Wagner, Eric J; Lazar, Mitchell A; Shilatifard, Ali; Shiekhattar, Ramin

Integrator regulates transcriptional initiation and pause release following activation Journal Article

In: Mol Cell, vol. 56, no. 1, pp. 128–139, 2014, ISSN: 1097-4164.

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Hoeksema, Marten A; Gijbels, Marion Jj; den Bossche, Jan Van; van der Velden, Saskia; Sijm, Ayestha; Neele, Annette E; Seijkens, Tom; Stöger, J Lauran; Meiler, Svenja; Boshuizen, Marieke Cs; Dallinga-Thie, Geesje M; Levels, Johannes Hm; Boon, Louis; Mullican, Shannon E; Spann, Nathanael J; Cleutjens, Jack P; Glass, Chris K; Lazar, Mitchell A; de Vries, Carlie Jm; Biessen, Erik Al; Daemen, Mat Jap; Lutgens, Esther; de Winther, Menno Pj

Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions Journal Article

In: EMBO Mol Med, vol. 6, no. 9, pp. 1124–1132, 2014, ISSN: 1757-4684.

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Lewandowski, Sara L; Janardhan, Harish P; Smee, Kevin M; Bachman, Marcos; Sun, Zheng; Lazar, Mitchell A; Trivedi, Chinmay M

Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis Journal Article

In: Hum Mol Genet, vol. 23, no. 14, pp. 3801–3809, 2014, ISSN: 1460-2083.

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Lefterova, Martina I; Haakonsson, Anders K; Lazar, Mitchell A; Mandrup, Susanne

PPARγ and the global map of adipogenesis and beyond Journal Article

In: Trends Endocrinol Metab, vol. 25, no. 6, pp. 293–302, 2014, ISSN: 1879-3061.

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Step, Sonia E; Lim, Hee-Woong; Marinis, Jill M; Prokesch, Andreas; Steger, David J; You, Seo-Hee; Won, Kyoung-Jae; Lazar, Mitchell A

Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers Journal Article

In: Genes Dev, vol. 28, no. 9, pp. 1018–1028, 2014, ISSN: 1549-5477.

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Jager, Jennifer; O'Brien, W Timothy; Manlove, Jessica; Krizman, Elizabeth N; Fang, Bin; Gerhart-Hines, Zachary; Robinson, Michael B; Klein, Peter S; Lazar, Mitchell A

Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbα Journal Article

In: Mol Endocrinol, vol. 28, no. 4, pp. 490–498, 2014, ISSN: 1944-9917.

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Lee, Sahmin; Lee, Hyun-Chae; Kwon, Yoo-Wook; Lee, Sang Eun; Cho, Youngjin; Kim, Joonoh; Lee, Soobeom; Kim, Ju-Young; Lee, Jaewon; Yang, Han-Mo; Mook-Jung, Inhee; Nam, Ky-Youb; Chung, Junho; Lazar, Mitchell A; Kim, Hyo-Soo

Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes Journal Article

In: Cell Metab, vol. 19, no. 3, pp. 484–497, 2014, ISSN: 1932-7420.

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2013

Sun, Zheng; Feng, Dan; Fang, Bin; Mullican, Shannon E; You, Seo-Hee; Lim, Hee-Woong; Everett, Logan J; Nabel, Christopher S; Li, Yun; Selvakumaran, Vignesh; Won, Kyoung-Jae; Lazar, Mitchell A

Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor Journal Article

In: Mol Cell, vol. 52, no. 6, pp. 769–782, 2013, ISSN: 1097-4164.

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Alenghat, Theresa; Osborne, Lisa C; Saenz, Steven A; Kobuley, Dmytro; Ziegler, Carly G K; Mullican, Shannon E; Choi, Inchan; Grunberg, Stephanie; Sinha, Rohini; Wynosky-Dolfi, Meghan; Snyder, Annelise; Giacomin, Paul R; Joyce, Karen L; Hoang, Tram B; Bewtra, Meenakshi; Brodsky, Igor E; Sonnenberg, Gregory F; Bushman, Frederic D; Won, Kyoung-Jae; Lazar, Mitchell A; Artis, David

Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis Journal Article

In: Nature, vol. 504, no. 7478, pp. 153–157, 2013, ISSN: 1476-4687.

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Mullican, Shannon E; Dispirito, Joanna R; Lazar, Mitchell A

The orphan nuclear receptors at their 25-year reunion Journal Article

In: J Mol Endocrinol, vol. 51, no. 3, pp. T115–T140, 2013, ISSN: 1479-6813.

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266 entries « 2 of 6 »